Virulence Factors of Periodontal Pathogens and Their Specific Targets in the Oral Epithelial Barrier

Basma Fathi Alanbari; Firas Bashir Al-Taweel; Paul Roy Cooper

doi:10.54133/ajms.v10i1.2662

Authors

Basma Fathi Alanbari Department of Periodontics, College of Dentistry, Al-Rafidain University, Baghdad, Iraq https://orcid.org/0000-0002-3165-2453
Firas Bashir Al-Taweel Department of Periodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0003-1594-885X
Paul Roy Cooper Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, Dunedin, New Zealand https://orcid.org/0000-0003-1305-7287

DOI:

https://doi.org/10.54133/ajms.v10i1.2662

Keywords:

Epithelial barrier integrity, Epithelial junctions , Keratinocyte , Periodontal pathogen , Virulence factor

Abstract

Background: The exploration of the epithelial targets of periodontal pathogens is crucial for our understanding of the underlying mechanisms of the host immune response and periodontal disease pathogenesis. Objective: To comprehensively review the current knowledge and key findings from relevant studies that contribute to this understanding. Source: PubMed database of the US National Library of Medicine. Study selection: Original articles (in vitro studies) published in the English language only and available as free text were included. Conclusions: Periodontal pathogen virulence factors are capable of directly targeting keratinocyte adhesion proteins, leading to the deterioration of epithelial barrier integrity, resulting in disease progression.

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