Systemic Melatonin Supplementation as an Adjunct to Non-Surgical Periodontal Treatment in Obese Patients with Periodontitis

Hussam Sami Ismail; Maha Shukri Mahmood; Athraa Ali Mahmood

doi:10.54133/ajms.v5i1S.385

Authors

Hussam Sami Ismail Department of Periodontics, College of Dentistry, AL-Ayen University, Nasiriyah, Iraq
Maha Shukri Mahmood Department of Periodontics, College of Dentistry, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-5754-6456
Athraa Ali Mahmood Department of Oral Surgery and Periodontics, College of Dentistry, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0000-0002-1981-2768

DOI:

https://doi.org/10.54133/ajms.v5i1S.385

Keywords:

Obesity, Melatonin, Periodontitis, Public health, RANKL

Abstract

Background: Obesity is considered an important risk factor for periodontal disease. It has been reported that reactive oxygen species linking both diseases, systemic melatonin supplementation as antioxidant therapy, was addressed as an adjuvant to scaling and root surface debridement (SRP) to enhance the treatment of periodontitis. Objective: To investigate the efficacy of systemic melatonin administration in periodontitis-obese patients as an adjuvant to scaling and root surface debridement (SRP). Methods: A randomized clinical trial was conducted at a dental-specialized center. Eighty subjects were included and allocated into group-I: twenty periodontium-healthy, normal-weight people; group-II: 30 obese patients with stage-III treated only with SRP; and group-III: 30 obese patients with stage-III periodontitis treated with SRP and 5mg melatonin. periodontitis and subjected to estimation, serum levels of Receptor Activator of Nuclear Factor-Kappa B Ligand (RANKL) were estimated in all groups. Probing pocket depth (PPD), bleeding on probing (BOP), and relative attachment level (RAL) were estimated in Groups II and III at baseline and after a one-month visit. Results: RANKL baseline visits were significantly different between the control and studied groups, with no significant difference in clinical parameters except for PPD. The 2^nd visit showed a significant difference in BOP score-1 compared to RAL and BOP score 0. In the second visit, only weak negative and positive significant correlations were found between RANKL and BOP. Conclusion: Daily use of 5 mg of melatonin improves periodontal parameters and decreases serum RANKL levels.

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