Topically Applied Glycerol-Based Turmeric Extract Formulation Ameliorates Diabetic Foot Ulcer: A Case Report

Abstract

Diabetic foot ulcers (D-FUs) are a severe complication that affects up to 34% of diabetic individuals. Approximately 20% of cases result in amputation and a doubled 10-year mortality risk. Although sophisticated therapies have achieved some success, there is a need for effective alternatives. The active compound curcumin of turmeric (Curcuma longa) possesses antimicrobial, antioxidant, and anti-inflammatory properties that may facilitate wound healing. A 41-year-old male presented with a two-month duration of antibiotic-resistant D-FU and had an inadequately controlled 12-year history of type 2 diabetes. The ulcer remained unresponsive despite conventional interventions, such as antibiotics. After saline cleansing, a topical turmeric extract glycerol-based formulation was applied to the wound daily. The formulation was freshly prepared by combining 1:1 g/ml of turmeric extract powder with glycerol. The turmeric extract treatment resulted in a substantial improvement in the condition of the lesion over 35 days. Exudate and erythema decreased within seven days, the infection had resolved, and the lesion had significantly healed by day 35. This case report indicates that turmeric extract has the potential to serve as a cost-effective adjunctive therapy for chronic D-FUs. However, additional research is necessary to optimize curcumin formulation to enhance its pharmacokinetics and to elucidate curcumin wound-healing mechanisms to promote diabetic wound healing and reduce related complications.