Evaluation of the Wound-Healing Activity and Apoptotic Induction of New Quinazolinone Derivatives

Mohammed Abdulameer Oleiwi; Munaf Hashim Zalzala; Alaa Radhi Khudhair; Mohammed Kamil Hadi; Zahraa Duraid Abdulazeez

doi:10.54133/ajms.v6i2.640

Authors

Mohammed Abdulameer Oleiwi Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq
Munaf Hashim Zalzala Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0003-0552-6469
Alaa Radhi Khudhair Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0003-0513-9960
Mohammed Kamil Hadi Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0001-5257-2332
Zahraa Duraid Abdulazeez Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.54133/ajms.v6i2.640

Keywords:

Apoptosis, Breast cancer, Lung adenocarcinoma, Quinazolinone, Scratch test

Abstract

Background: Chemotherapeutic medication treatment for cancer is typically used in conjunction with other techniques as part of a routine regimen. It is well established that the capacity of different chemotherapeutic drugs to induce apoptosis is correlated with their anticancer efficacy. Quinazolinone-based drugs have demonstrated excellent responses from several cancer cell types. These substances have a lot of potential for use as building blocks in the creation of apoptosis inducers. Objective: To assess the new quinazolinone derivatives (M1 and M2) that were recently synthesized for their potential to halt wound healing and to use the acridine orange/propidium iodide (AO/PI) double stain to assess their capacity to induce apoptosis in the chosen cancer cell lines. Methods: Using the breast carcinoma cell line (MCF-7) and the lung adenocarcinoma cell line (A549), two quinazolinone derivatives (M1 and M2) were investigated for their capacity to inhibit wound healing and induce apoptosis. Results: In both cell lines, the chemicals were found to be effective inducers of apoptosis and to considerably limit wound healing. Conclusions: In cancer cell lines (MCF-7 and A549), compounds M1 and M2 efficiently inhibited wound repair and triggered apoptosis.

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