Effect of Grape Seed Proanthocyanidins Supplement on the Incidence of Recurrent Urinary Tract Infections in a Sample of Iraqi Diabetic Patients

Saba Hameed Majeed; Bahir Abdul Razzaq Mshimesh; Isam Noori Salman; Mohammed Mahmood Mohammed

doi:10.54133/ajms.v7i1(Special).871

Authors

Saba Hameed Majeed Department of Clinical Pharmacy, College of Pharmacy, Al-Nahrain University, Baghdad, Iraq https://orcid.org/0000-0002-1322-536X
Bahir Abdul Razzaq Mshimesh Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0000-0003-4412-8690
Isam Noori Salman National Diabetes Center for Treatment and Research, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0000-0003-2813-3879
Mohammed Mahmood Mohammed Department of Clinical Pharmacy, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0000-0002-1205-4829

DOI:

https://doi.org/10.54133/ajms.v7i1(Special).871

Keywords:

Grape seed extract, Metformin, Proanthocyanidin, T2DM, UTIs, Uropathogenicity

Abstract

Background: Proanthocyanidin is often used to prevent urinary tract infections (UTIs) in susceptible E. coli strains. Objective: To explore how grape seed proanthocyanidin extract (GSPE) affects type 2 diabetic patients (T2DM) with recurrent urinary tract infections (rUTIs). Method: The efficacy of GSPE in the treatment of T2DM with rUTIs was assessed in this randomized, single-blind controlled study. Sixty adults with diagnosed T2DPs and urinary tract infections were randomly assigned to treatment for 12 weeks with metformin (0.5 g t.i.d.) in Group A (Control Group) and a combination of GSPE (300 mg q.d.) and metformin (0.5 g t.i.d.), Group B, with the end of follow-up being 24 weeks, according to the study. Results: The medicinal plant GSPE reduces the recurrence of urinary tract infections in patients with T2DM after 12 weeks of treatment, compared with pre-treatment values and the control group. After 12 weeks of treatment for T2DM, fasting plasma glucose levels, creatinine, urea, and uric acid in both groups decreased non-significantly compared to control. There were fewer recurrent UTIs in the intervention group (77.8%), the control group (48.1%), and the GSPE (7.1%), compared to the control group (12.7%), the GSPE (7.1%), and the intervention group (33.7%) over the course of 24 weeks. Conclusions: Utilizing GSPE to treat, prevent, and minimize recurrent urinary tract infections in T2DM will help them better grasp the benefits and hazards associated with the daily administration of an appropriate GSPE dose.

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References

Altaie AH. Association between gallstones and diabetics type 2 Iraqi patients. Iraqi J Pharm Sci. 201;120(2):38-43. doi: 10.31351/vol20iss2pp38-43.

Hussein AS, Kadhim KA, Fadil SM. Effect the Pharmaceutical care and health education on knowledge and disease control for type 2 diabetes mellitus patients: A sample of Iraqi patients. Al Mustansiriyah J Pharm Sci. 2020;20(1):40-54. doi: 10.32947/ajps.v20i1.684.

Kuo KM, Talley P, Kao Y, Huang CH. A multi-class classification model for supporting the diagnosis of type II diabetes mellitus. PeerJ. 2020;8: e9920. doi: 10.7717/peerj.9920.

Namiq HS, Obeid KA, Mohammed DA. Role of pharmaceutical care in type 2 diabetic patients in Kirkuk City. Al Mustansiriyah J Pharm Sci. 2020;20(4):169-181. doi: 10.32947/ajps.v20i4.788.

Mansour AA, Al-Maliky AA, Kasem B, Jabar A, Mosbeh KA. Prevalence of diagnosed and undiagnosed diabetes mellitus in adults aged 19 years and older in Basrah, Iraq. Diabetes Metab Syndr Obes. 2014;7:139-144. doi: 10.2147/DMSO.S59652.

Chávez-Reyes J, Escárcega-González CE, Chavira-Suárez E, León-Buitimea A, et al. Susceptibility for some infectious diseases in patients with diabetes: The key role of glycemia. Front Public Health. 2021,9:559595. doi: 10.3389/fpubh.2021.559595.

Bajpai A, Tilley DG. The Role of leukocytes in diabetic cardiomyopathy. Front Physiol. 2018;9:1547. doi: 10.3389/fphys.2018.01547/.

Shah MA, Kassab YW, Farooq MJ, Khalid T, Ifzaal M. Recent studies on urinary tract infections in diabetes mellitus. Health Sci J. 2020;14(3):724. doi: 10.36648/1791-809X.14.3.724.

Bergamin PA, Kiosoglous AJ. Non-surgical management of recurrent urinary tract infections in women. Transl Androl Urol. 2017;6(Suppl 2):S142-S152.

Zhou Y, Zhou Z, Zheng L, Gong Z, Li Y, Jin Y, et al. Urinary tract infections caused by uropathogenic Escherichia coli: Mechanisms of infection and treatment options. Int J Mol Sci. 2023;24(13):10537. doi: 10.3390/ijms241310537.

El-Ghar MA, Farg H, Sharaf DE, El-Diasty T. CT and MRI in urinary tract infections: A spectrum of different imaging findings. Medicina (Kaunas). 2021;57(1):32. doi: 10.3390/medicina57010032.

Shaheen G, Akram M, Jabeen F, Ali Shah SM, Munir N, Daniyal M, et al. Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review. Clin Exp Pharmacol Physiol. 2019;46(7):613-624. doi: 10.1111/1440-1681.13092.

Terlizzi ME, Gribaudo G and Maffei ME. UroPathogenic Escherichia coli (UPEC) infections: Virulence factors, bladder responses, antibiotic, and non-antibiotic antimicrobial strategies. Front Microbiol. 2017;8:1566. doi: 10.3389/fmicb.2017.01566.

Rauf A, Imran M, Abu-Izneid T, Iahtisham-Ul-Haq, Patel S, Pan X, Naz S, et al. Proanthocyanidins: A comprehensive review. Biomed Pharmacother. 2019;116:108999. doi: 10.1016/j.biopha.2019.108999.

Sayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S19-S40. doi: 10.2337/dc23-S002.

Swatesutipun V. Can recurrent UTIs in women be cured? Review article. Continence Rep. 2023;5:100021. doi: 10.1016/j.contre.2023.100021.

Kline KA, Lewis AL. Gram-positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract. Microbiol Spectr. 2016;4(2). doi: 10.1128/microbiolspec.UTI-0012-2012.

Walelgn B, Abdu M, Kumar P. The occurrence of urinary tract infection and determinant factors among diabetic patients at Dessie Referral Hospital, South Wollo, Northeast Ethiopia. SAGE Open Med. 2021; 9:20503121211060614. doi: 10.1177/20503121211060614.

Alsahli M, Gerich JE. Renal glucose metabolism in normal physiological conditions and in diabetes. Diabetes Res Clin Pract. 2017;133:1-9. doi: 10.1016/j.diabres.2017.07.033.

Nitzan O, Elias M, Chazan B, Saliba W. Urinary tract infections in patients with type 2 diabetes mellitus: review of prevalence, diagnosis, and management. Diabetes Metab Syndr Obes. 2015;8:129-136. doi: 10.2147/DMSO.S51792.

Bergamin PA, Kiosoglous AJ. Non-surgical management of recurrent urinary tract infections in women. Transl Androl Urol. 2017;6(Suppl 2):S142-S152. doi: 10.21037/tau.2017.06.09.

Aggarwal N, Leslie SW, Lotfollahzadeh S, (Eds.), Recurrent urinary tract infections. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK557479/

Al-Badr A, Al-Shaikh G. Recurrent urinary tract infections management in women: A review. Sultan Qaboos Univ Med J. 2013;13(3):359-367. doi: 10.12816/0003256.

Gupta V, Nag D, Garg P. Recurrent urinary tract infections in women: How promising is the use of probiotics? Indian J Med Microbiol. 2017;35(3):347-354. doi: 10.4103/ijmm.IJMM_16_292.

Geetha RV, Roy A, Lakshmi T. Nature’s weapon against urinary tract infections. Int J Drug Dev Res. 2011;3(3):85-100.

Loubet P, Ranfaing J, Dinh A, Dunyach-Remy C, Bernard L, Bruyère F, et al. Alternative therapeutic options to antibiotics for the treatment of urinary tract infections. Front Microbiol. 2020;11:1509. doi: 10.3389/fmicb.2020.01509.

Ranjitha CY, Priyanka S, Deepika R, Smitha Rani GP, Sahana J, Prashith Kekuda TR. Antimicrobial activity of grape seed extract. World J Pharmacy Pharm Sci. 2014;3(8):1483-1488.

Sánchez-Patán F, Barroso E, van de Wiele T, Jiménez-Girón A, Martín-Alvarez PJ, Moreno-Arribas MV, et al. Comparative in vitro fermentations of cranberry and grape seed polyphenols with colonic microbiota. Food Chem. 2015;183:273-282. doi: 10.1016/j.foodchem.2015.03.061.

Varzakas T, Zakynthinos G, Verpoort F. Plant food residues as a source of nutraceuticals and functional foods. Foods. 2016;5:88. doi: 10.3390/foods5040088.

Asbaghi O, Nazarian B, Reiner Ž, Amirani E, Kolahdooz F, Chamani M, et al. The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2020;34(2):239-253. doi: 10.1002/ptr.6518.

Mohammad A, Shahnaz T, Sorayya K. Effect of 8 weeks' supplementation grape seed extract on insulin resistance in iranian adolescents with metabolic syndrome: A randomized controlled trial. Diabetes Metab Syndr. 2021;15(1):197-203. doi: 10.1016/j.dsx.2020.12.028.

Moodi V, Abedi S, Esmaeilpour M, Asbaghi O, Izadi F, Shirinbakhshmasoleh M, et al. The effect of grapes/grape products on glycemic response: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2021;35(9):5053-5067. doi: 10.1002/ptr.7135.

Turki K, Charradi K, Boukhalfa H, Belhaj M, Limam F, Aouani E. Grape seed powder improves renal failure of chronic kidney disease patients. EXCLI J. 2016;15:424-433. doi: 10.17179/excli2016-363.

Sano A. Safety assessment of 4-week oral intake of proanthocyanidin – rich grape seed extract in healthy subjects. Food Chem Toxicol. 2017;108:519-523. doi: 10.1016/j.fct.2016.11.021.

Amin KA. Ahmed RR, Hozayen WG, MahmoudnSS, Alshehri FS, Al-Muzafar HM. Renoprotective effect of grape seed extract in diabetic nephropathy by attenuating hyperglycemia-facilitated oxidative stress. Int J Clin Exp Med. 2018;11(11):12285-12293.

Yusong D, Haiyan Li, Yang Li, Liu D, Zhang L, Wang T, et al. Protective effects of grape seed proanthocyanidins on the kidneys of diabetic rats through the Nrf2 signalling pathway. Evid Based Complement Altern Med. 2020;2020:9. doi: 10.1155/2020/5205903.

Kwatra B. A review on potential properties and therapeutic applications of grape seed extract. World J Pharm Res. 2020;9(5):2519-2540. doi: 10.20959/wjpr20205-17514.

Howell AB, Dreyfus JF, Chughtai B. Differences in urinary bacterial anti-adhesion activity after intake of cranberry dietary supplements with soluble versus insoluble proanthocyanidins. J Diet Suppl. 2022;19(5):621-639. doi: 10.1080/19390211.2021.1908480.

Sochorova L, Prusova B, Cebova M, Jurikova T, Mlcek J, Adamkova A, et al. Health effects of grape seed and skin extracts and their influence on biochemical markers. Molecules. 2020;25(22):5311. doi: 10.3390/molecules25225311.