Role of Human β-Defensin-3 in Rheumatoid Arthritis: An Observational Single-Center Study

Authors

  • Noor Ulhuda Ghazi Mohammed College of Science for Women, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0003-3549-1578
  • Faiq Isho Gorial Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-2760-5566
  • Fayhaa Magdad Khaleel Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-9951-2086
  • Baydaa Ahmed Abed National Diabetes Center, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0000-0002-8895-7901
  • Samara Ali Mutar Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq
  • Layla Othman Farhan Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-5961-1338
  • Isam Noori Salman National Diabetes Center, Mustansiriyah University, Baghdad, Iraq

DOI:

https://doi.org/10.54133/ajms.v5i1S.289

Keywords:

Beta-human defensin-3, DAS28, Defensins, Pro-inflammatory cytokines, Rheumatoid arthritis

Abstract

Background: It's believed that HBD-3 is involved in the tissue remodeling process of articular cartilage. Also, HBD-3 has anti-inflammatory properties. Objectives: The purpose of this study is to assay human beta-defensine-3 (HBD-3) in serum from rheumatoid arthritis (RA) patients and investigate its correlation with proinflammatory cytokines. Methods: In this case-control study, fifty-eight RA patients were aged 20–65 years, and 29 age-matched healthy subjects (HS) had no inflammatory rheumatic diseases. The disease activity score-28 joint erythrocyte sedimentation rate (DAS28-ESR) was used to measure RA activity. CRP, ACPA, HBD-3, TNF-α, and IL-1β were assessed using the enzyme-linked immunosorbent assay technique (ELISA). Results: There was a significant increase in RF, ACPA, CRP, proinflammatory cytokines, and HBD-3 in the RA group compared with the HS group. There was no significant difference in HBD-3 levels according to the activity of diseases. The results of the correlation between HBD-3 and proinflammatory cytokines showed a significant positive relationship in the RA group. Conclusions: Inflammatory markers and S.HBD-3 demonstrated fair diagnostic performance to differentiate RA from HS. The current study supports the hypothesis that there is a correlation between HBD-3 and the immunoregulatory response.

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References

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Published

2023-11-02

How to Cite

Mohammed, N. U. G., Gorial, F. I., Khaleel, F. M., Abed , B. A., Mutar, S. A., Farhan , L. O., & Salman, I. N. (2023). Role of Human β-Defensin-3 in Rheumatoid Arthritis: An Observational Single-Center Study . Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), 5(1S), S71–75. https://doi.org/10.54133/ajms.v5i1S.289

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