Brain MRI Appearance of a Scalp Proliferating Trichilemmal Tumor: Case Report
DOI:
https://doi.org/10.54133/ajms.v9i2.2500Keywords:
Brain MRI, Proliferating trichomonal tumor, Trichilemmal cystAbstract
Background: The proliferating trichilemmal tumor is a solid-cystic lesion in the hair follicle's isthmus. Most reported cases of proliferating trichilemmal tumors (PTT) exhibit a benign growth pattern; however, aggressive behavior can occasionally occur, characterized by invasion beyond the cyst wall that simulates squamous cell carcinoma. Additionally, local recurrence and distant metastasis have been observed. Case presentation: A 57-year-old female with a histopathology-proven proliferating trichilemmal tumor presented with a recurrent scalp mass. It was a sizable occipital scalp mass that was ruptured to the skin with purulent discharge and surrounded by cellulitis. A brain MRI was performed, which showed a large mass on the right side of the occipital scalp. The mass was mostly solid and showed an isointense signal on the pre-contrast T1, T2, and FLAIR sequences, with some low-T1 and high-T2 signal intensity cystic areas. Homogenous enhancement of the solid part on post-contrast T1WI was evident, and no diffusion restriction was noted. The calvarium and intracranial extension did not show any gross invasion. In conclusion, imaging findings of proliferating trichilemmal tumors may help differentiate between closely similar lesions. It is also beneficial to evaluate surrounding soft tissue and intracranial extension denoting a malignant transformation.
Downloads
References
Montella M, Farabini A, Lucà S, Donati M. Malignant proliferating trichilemmal tumor: A rare neoplasm in a rare location. Case report and review of literature. Ann Res Oncol. 2022;2(4):265-271. doi: 10.48286/aro.2022.55.. DOI: https://doi.org/10.48286/aro.2022.55
Requena L, Crowson AN, Kaddu S, et al. Proliferating trichilemmal tumor. In: WHO Classification of Skin Tumors 4. Lyon, France: IARC Press, 2018, pp. 196–197.
Ramaswamy AS, Manjunatha HK, Sunilkumar B, Arunkumar SP. Morphological spectrum of pilar cysts. N Am J Med Sci. 2013;5(2):124-128. doi: 10.4103/1947-2714.107532. DOI: https://doi.org/10.4103/1947-2714.107532
Wang M, Zhu J, Wang C, Chen J. A proliferating trichilemmal tumor at an uncommon site treated with radical excision: a case report and literature review. Cureus. 2024;16(4):e58341. doi: 10.7759/cureus.58341. DOI: https://doi.org/10.7759/cureus.58341
Fortarezza F, Cazzato G, Dei Tos AP. The 2023 World Health Organization updates on skin tumors: advances since the 2018 edition. Pathologica. 2024;116(4):193 206. doi: 10.32074/1591 951X 1006. DOI: https://doi.org/10.32074/1591-951X-1006
Wang G, Zhou X, Luo J, Hu Q, Zhang J. Case report: Malignant proliferating trichilemmal tumor of the thumb. Front Oncol. 2022;12:1005206. doi: 10.3389/fonc.2022.1005206 DOI: https://doi.org/10.3389/fonc.2022.1005206
Kawaguchi M, Kato H, Suzui N, Miyazaki T, Tomita H, Hara A, et al. Imaging findings of trichilemmal cyst and proliferating trichilemmal tumour. Neuroradiol J. 2021;34(6):615-621. doi: 10.1177/19714009211017789. DOI: https://doi.org/10.1177/19714009211017789
Mamatha HG, Pranitha SL, Narayanan GS, Arpitha S. A rare case of proliferating trichilemmal tumor treated with radiotherapy. J Med Sci Clin Res. 2024;12(02):78-82. doi: 10.18535/jmscr/v12i02.11. DOI: https://doi.org/10.18535/jmscr/v12i02.11
Durairaj AR, Mahipathy SR, Vivakaran TT, Harikrishnan V, Esakki M. Malignant proliferative trichilemmal tumour of the nape of the neck - A case report. J Clin Diagn Res. 2016;10(2):PD19-20. doi: 10.7860/JCDR/2016/17167.7258. DOI: https://doi.org/10.7860/JCDR/2016/17167.7258
Valério E, Parro FHS, de Macedo MP, Pinto CA. Proliferating trichilemmal cyst with clinical, radiological, macroscopic, and microscopic correlation. Anais Bras Dermatol. 2019;94(4):452–454. doi: 10.1590/abd1806 4841.20198199. DOI: https://doi.org/10.1590/abd1806-4841.20198199
Sharma A, Gupta R, Mehta S, Singh P. A rare case of a malignant proliferating trichilemmal tumor: A molecular study harboring potential therapeutic significance and a review of literature. J Cutan Pathol. 2025;52(3):210–218. doi: 10.1002/cup.3152.
Sánchez-Gómez LM, Martínez-González CL, Sánchez-Gómez C, Martínez-González I, Martínez-Gómez JM. Proliferating pilar tumors in the scalp over a period of 23 years in a general hospital in Mexico City. Int J Trichology. 2023;15(3):109–113. doi: 10.4103/ijt.ijt_86_22.
Kim HJ, Kim TS, Lee KH, Kim YM, Suh CH. Proliferating trichilemmal tumors: CT and MR imaging findings in two cases, one with malignant transformation. Am J Neuroradiol. 2001;22(1):180-183. PMID: 11158906.
Tan LA, Harbhajanka A, Kasliwal MK, Nag S, Munoz LF. Giant trichilemmal cyst of the scalp. Neurol India. 2016;64(2):357-358. doi: 10.4103/0028-3886.177589. DOI: https://doi.org/10.4103/0028-3886.177589
Fieleke DR, Goldstein GD. Malignant proliferating trichilemmal tumor treated with Mohs surgery: proposed protocol for diagnostic work-up and treatment. Dermatol Surg. 2015;41(2):292-294. doi: 10.1097/DSS.0000000000000269. DOI: https://doi.org/10.1097/DSS.0000000000000269
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 )

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Published by Al-Rafidain University College. This is an open access journal issued under the CC BY-NC-SA 4.0 license (https://creativecommons.org/licenses/by-nc-sa/4.0/).



