Effects of Valsartan on the Gingival Architecture of Rats: Histological Study

Basma Fathi Alanbari; Noor Abdulkareem Razouki; Hadeel Ali Mahdi

doi:10.54133/ajms.v8i2.1939

Authors

Basma Fathi Alanbari Periodontics Branch, Department of Dentistry, AL-Rafidain University College, Baghdad, Iraq
Noor Abdulkareem Razouki Department of Oral and Maxillofacial Surgery, College of Dentistry, Ibn Sina University for Medical and Pharmaceutical Sciences, Baghdad, Iraq https://orcid.org/0000-0002-2118-3358
Hadeel Ali Mahdi Orthodontics Branch, Dentistry Department, Al-Israa University, Baghdad, Iraq

DOI:

https://doi.org/10.54133/ajms.v8i2.1939

Keywords:

Angiotensin II receptor blockers, Anti-hypertensive, Gingiva, Histology, Valsartan

Abstract

Background: Valsartan is an angiotensin II receptor inhibitor prescribed to regulate heart pressure. The bulk of studies documented the impact of antihypertensive drugs on the gingival tissues; however, none have investigated the effect of valsartan on the gingival architecture. Objective: To investigate the histological effect of valsartan administration on the gingival tissue architecture in rats. Methods: Twenty Wistar male rats (2–3 months old) were randomly assigned to the control and valsartan groups. 10mg/kg/day valsartan was administered subcutaneously for two weeks. Then all the animals were sacrificed, and full-thickness samples of gingival tissue were harvested from the palatal aspect of the rat's molar teeth and prepared for examination under a microscope. Results: Although the results revealed that the valsartan group showed thicker epithelium (mean=0.1280 mm) compared to the control group, the difference did not reach statistical significance. In the lamina propria, the thickness change was statistically significant (0.07400±0.0143 mm) compared to the controls (0.0573±0.00696). The submucosa thickness measures were equivalent for both groups. The count of blood vessels showed no variation between the two experimental groups. Conclusions: Treatment with valsartan resulted in a significant increase in lamina propria thickness with no influence on epithelial thickness, submucosal thickness, or blood vessel count in rat gingival tissue.

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