Quality Indicators of Antimicrobials Prescribing in Iraq: A Scoping Review

Authors

  • Jaafer Mosadek Kurmanji School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia; Department of Clinical Pharmacy, College of Pharmacy, Al-Esraa University, Baghdad, Iraq https://orcid.org/0000-0003-3216-2736
  • Ooi Guat See School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia
  • Ali Azeez Al- Jumaili Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad, Iraq; Department of Public Health, University of California Davis School of Medicine, CA, USA; College of Pharmacy, University of Iowa, IA, USA
  • Manal Mohammed Younus Iraqi Pharmacovigilance Center, Iraqi Ministry of Health, Baghdad, Iraq https://orcid.org/0000-0001-9475-5700

DOI:

https://doi.org/10.54133/ajms.v7i1.1227

Keywords:

Antimicrobial, Iraq, Quality indicators, Point prevalence survey

Abstract

Background: Antimicrobial overconsumption is a global public health concern, particularly in the Middle East, where illnesses and antibiotic use are on the increase. Antimicrobial resistance is associated with excessive usage. As a Middle Eastern country, Iraq provides a suitable baseline for situating it amid its neighbors. We use quality indicators to reliably identify bad practice and recommend updated antibiotic prescribing practices for hospitalized patients. Objectives: To compare antimicrobial prescribing quality metrics in Iraqi hospitals to those in Middle Eastern nations. Methods: We conducted a literature review using a point prevalence survey to assess the inappropriateness of antimicrobial usage in hospitals in the Middle East countries after evaluating literature from sources such as Scopus, Web of Science, PubMed, and EBSCO. To examine the Iraqi scenario, we used four primary quality indicators: guidelines compliance, stop/review note documentation, parenteral administration, and the selection of targeted antibios. Results: According to the study, Iraq's guideline availability ranged from 0% to 7%, which was lower than Jordan's optimum of 95.8%. The rate of stop/review documentation was approximately 0.4%, which was lower than the maximum rate of 72% in the UAE; and only 1.2% of prescriptions were targeted antibiotics, which was higher than Iran's 0%. Regarding parenteral antibiotics, Iraq reported that 89.9% of the antibiotics used were injectable, which is consistent with most comparable nations (74%-100%). Conclusions: In Iraqi hospitals, antimicrobials are used inappropriately. An immediate effort is necessary to update national records, with ongoing follow-up by regular prevalence surveys.

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References

Murray CJL, Ikuta KS, Bisignano C, Rao P, Wool E, McManigal B, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629-655. doi: 10.1016/s0140-6736(21)02724-0.

Chokshi A, Sifri Z, Cennimo D, Horng H. Global contributors to antibiotic resistance. J Glob Infect Dis. 2019;11(1):36-42. doi: 10.4103/jgid.jgid_110_18.

Talaat M, Tolba S, Abdou E, Sarhan M, Gomaa M, Hutin YJF. Over-prescription and overuse of antimicrobials in the Eastern Mediterranean region: The urgent need for antimicrobial stewardship programs with access, watch, and reserve adoption. 2022;11(12):1773. doi: 10.3390/antibiotics11121773.

Haseeb A, Saleem Z, Maqadmi AF, Allehyani RA, Mahrous AJ, Elrggal ME, et al. Ongoing strategies to improve antimicrobial utilization in hospitals across the Middle East and North Africa (MENA): Findings and implications. Antibiotics (Basel). 2023;12(5). doi: 10.3390/antibiotics12050827.

Al-Orphaly M, Hadi HA, Eltayeb FK, Al-Hail H, Samuel BG, Sultan AA, et al. Epidemiology of multidrug-resistant Pseudomonas aeruginosa in the Middle East and North Africa region. mSphere. 2021;6(3). doi: 10.1128/mSphere.00202-21.

Nimer NA. Nosocomial infection and antibiotic-resistant threat in the Middle East. Infect Drug Resist. 2022;15:631-639. doi: 10.2147/idr.S351755.

Devi S. AMR in the Middle East: "a perfect storm". Lancet. 2019;394(10206):1311-1312. doi: 10.1016/S0140-6736(19)32306-2.

Bert F, Previti C, Calabrese F, Scaioli G, Siliquini R. Antibiotics self-medication among children: A systematic review. Antibiotics (Basel). 2022;11(11):1583. doi: 10.3390/antibiotics11111583.

WHO. Global action plan on antimicrobial resistance. 2015 (Geneva: World Health Organization; 2015). Available at: www.who.int/publications/i/item/9789241509763

WHO_EMRO. Iraq develops national action plan to address antimicrobial resistance. 2017; Available at: http://www.emro.who.int/irq/iraq-news/moh-in-collaboration-with-who-develops-national-action-plan-tackling-antimicrobial-resistance-in-iraq.html

WHO. WHO policy guidance on integrated antimicrobial stewardship activities; 2021. Available at: https://doi.org/https://www.who.int/publications/i/item/9789240025530.

ECDC. Point prevalence survey of healthcare-associated infections and antimicrobial use in European acute care hospitals - ECDC PPS validation protocol version 3.1.2. 2019. Available at: https://doi.org/https://www.ecdc.europa.eu/en/publications-data/point-prevalence-survey-healthcare-associated-infections-and-antimicrobial-use-4

WHO. WHO methodology for point prevalence survey on antibiotic use in hospitals. 2019 (WHO/EMP/IAU/2018.01). Available at: https://doi.org/https://www.who.int/medicines/access/antimicrobial_resistance/WHO-EMP-IAU-2018_01/en/

PPS G. Global point prevalence survey of antimicrobial consumption and resistance (2019 GLOBAL-PPS). 2019. Available at: https://doi.org/http://www.global-pps.com/wp-content/uploads/2019/02/Global-PPS-2019-protocol.pdf

Pauwels I, Versporten A, Vermeulen H, Vlieghe E, Goossens H. Assessing the impact of the Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS) on hospital antimicrobial stewardship programs: results of a worldwide survey. Antimicrob Resist Infect Control. 2021;10(1):138. doi: 10.1186/s13756-021-01010-w.

Wagner B, Filice GA, Drekonja D, Greer N, MacDonald R, Rutks I, et al. Antimicrobial stewardship programs in inpatient hospital settings: a systematic review. Infect Control Hosp Epidemiol. 2014;35(10):1209-1228. doi: 10.1086/678057.

Davey P, Brown E, Fenelon L, Finch R, Gould I, Holmes A, et al. Systematic review of antimicrobial drug prescribing in hospitals. Emerg Infect Dis. 2006;12(2):211-216. doi: 10.3201/eid1202.050145.

Ohl CA LV. Antimicrobial stewardship for inpatient facilities. J Hosp Med. 2011;6(1):s4-s15. doi: 10.1002/jhm.881.

Kötter T, Blozik E, Scherer M. Methods for the guideline-based development of quality indicators--a systematic review. Implement Sci. 2012;7(1):21. doi: 10.1186/1748-5908-7-21.

O'Riordan F, Shiely F, Byrne S, Fleming A. Quality indicators for hospital antimicrobial stewardship programmes: a systematic review. J Antimicrob Chemother. 2021;76(6):1406-1419. doi: 10.1093/jac/dkab034.

Kallen MC, Prins JM. A Systematic review of quality indicators for appropriate antibiotic use in hospitalized adult patients. Infect Dis Rep. 2017;9(1):6821. doi: 10.4081/idr.2017.6821.

Morris AM. Antimicrobial stewardship programs: Appropriate measures and metrics to study their impact. Curr Treat Options Infect Dis. 2014;6(2):101-112. doi: 10.1007/s40506-014-0015-3.

Kurmanji JM, Hassali A, Versporten A, Younus M, Pauwels I, Goossens H, et al. Global point prevalence survey in five teaching hospitals in Baghdad, Iraq. Mediterr J Infect Microb Antimicrob. 2021;10:17. doi: 10.4274/mjima.galenos.2021.2020.17.

Kurdi A, Hasan AJ, Baker KI, Seaton RA, Ramzi ZS, Sneddon J, et al. A multicentre point prevalence survey of hospital antibiotic prescribing and quality indices in the Kurdistan regional government of Northern Iraq: the need for urgent action. Expert Rev Anti-infect Ther. 2021;19(6):805-814. doi: 10.1080/14787210.2021.1834852.

Soltani J, Pouladfar G, Versporten A, Sharland M, Goossens H, Jafarpour Z, et al. Point prevalence survey of antimicrobial prescription and infection in pediatric and neonatal wards of two Iranian teaching hospitals. J Clin Pract Res. 2019;41(1):25-32. doi: 10.5152/etd.2018.18191.

Soltani J, Versporten A, Goossens H, Pawels I, Moradi G, Yazdanifard P, et al. Point prevalence study of antibiotic consumption in Sanandaj hospitals, 2015-2017; Urgent implications for an antibiotic stewardship program. Sci J Kurd Univ Med Sci. 2022;27(5):108-125. doi: 10.52547/sjku.27.5.108.

Soltani J, Behzadi S, Pauwels I, Goossens H, Versporten A, Verhamme K, et al. Global-PPS targets for antimicrobial stewardship in pediatric patients at hospitals in Sanandaj, Western Iran, compared with Southeast Asian and European hospitals. J Glob Antimicrob Resist. 2024;36:473-481. doi: 10.1016/j.jgar.2024.01.011.

Alnajjar MS, Jawhar DS, Aburuz S, Saeed DA, Ibrahim AH. Point prevalence survey of antibiotic utilization in secondary care hospital in the United Arab Emirates. Pharmacy Pract. 2022;20(3):2685. doi: 10.18549/PharmPract.2022.3.2685.

Abdulrazzaq N, Chkhis A. Prevalence of antimicrobial use and healthcare-associated infections in the UAE: Results from the first nationwide point-prevalence survey. Infect Dis Now. 2024;54(4):104891. doi: 10.1016/j.idnow.2024.104891.

Ashour RH, Abdelkader EA, Hamdy O, Elmetwally M, Laimon W, Abd-Elaziz MA. The pattern of antimicrobial prescription at a tertiary health center in Egypt: A point survey and implications. Infect Drug Resist. 2022;15:6365-6378. doi: 10.2147/idr.S380693.

Kalem AK, Ayhan M, Hasanoğlu I, Kayaaslan B, Tasyaran MA, Guner R. Improper usage of antimicrobials: an issue of prophylaxis. Int J Infect Dis. 2018;73:137. doi: 10.1016/j.ijid.2018.04.3725.

Ergül AB, Gökçek İ, Çelik T, Torun YA. Assessment of inappropriate antibiotic use in pediatric patients: Point-prevalence study. Turk Pediatr Arch. 2018;53(1):17-23. doi: 10.5152/TurkPediatriArs.2018.5644.

Al Salman J, Al Agha R, Ebrahim Z, Al Majed M, Al Taitoon S, Al Tajer Z, et al. Antibiotics point prevalence. Bahrain Med Bull. 2017;39(4):220-224.

Nasr Z, Babiker A, Elbasheer M, Osman A, Elazzazy S, Wilby KJ. Practice implications of an antimicrobial stewardship intervention in a tertiary care teaching hospital, Qatar. East Mediter Health J. 2019;25(3):172-180. doi: 10.26719/emhj.18.026.

Al Matar M, Enani M, Binsaleh G, Roushdy H, Alokaili D, Al Bannai A, et al. Point prevalence survey of antibiotic use in 26 Saudi hospitals in 2016. J Infect Public Health. 2019;12(1):77-82. doi: 10.1016/j.jiph.2018.09.003.

Al Matar M, Enani M, Al Abdely H, Roshdy H, Binsaleh G. Antimicrobial usage in Saudi Ministry of Health Hospitals: Data from 2016 and 2017. J Infect Public Health. 2019;12(1):146. doi: 10.1016/j.jiph.2018.10.123.

Haseeb A, Faidah HS, Algethamy M, Alghamdi S, Alhazmi GA, Alshomrani AO, et al. Antimicrobial usage and resistance in Makkah region hospitals: A regional point prevalence survey of public hospitals. Int J Environ Res Public Health. 2021;19(1):254. doi: 10.3390/ijerph19010254.

Abu Hammour K, Al-Heyari E, Allan A, Versporten A, Goossens H, Abu Hammour G, et al. Antimicrobial consumption and resistance in a tertiary care hospital in Jordan: Results of an internet-based global point prevalence survey. Antibiotics (Basel). 2020;9(9):598. doi: 10.3390/antibiotics9090598.

Versporten A, Zarb P, Caniaux I, Gros MF, Drapier N, Miller M, et al. Antimicrobial consumption and resistance in adult hospital inpatients in 53 countries: results of an internet-based global point prevalence survey. Lancet Glob Health. 2018;6(6):e619-e629. doi: 10.1016/S2214-109X(18)30186-4.

Mittal A, Bhardwaj R, Mishra P, Rajput SK. Antimicrobials misuse/overuse: Adverse effect, mechanism, challenges and strategies to combat resistance. Open Biotechnol J. 2020. doi: 10.2174/1874070702014010107.

Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Safe. 2014;5(6):229-241. doi: 10.1177/2042098614554919.

Pasquau J, Sadyrbaeva S, De Jesús SE, Hidalgo-Tenorio C. The role of antimicrobial stewardship programs in the control of bacterial resistance. Rev Esp Quimioter. 2016;29(Suppl 1):47-51. PMID: 27608314.

Al Salman J, Al Dabal L, Bassetti M, Alfouzan WA, Al Maslamani M, Alraddadi B, et al. Promoting cross-regional collaboration in antimicrobial stewardship: Findings of an infectious diseases working group survey in Arab countries of the Middle East. J Infect Public Health. 2021;14(7):978-984. doi: 10.1016/j.jiph.2021.04.009.

Arif S, Sadeeqa S, Saleem Z. Patterns of antimicrobial use in hospitalized children: A repeated point prevalence survey from Pakistan. J Pediatr Infect Dis Soc. 2021;10(10):970-974. doi: 10.1093/jpids/piab026.

Nassr OA, Alridha AMA, Naser RA, Abbas RS. Antibiotic prescribing in the acute care in Iraq. Zendo. 2018;13:16. doi: 10.5281/zenodo.1474831.

Sartelli M, C Hardcastle T, Catena F, Chichom-Mefire A, Coccolini F, Dhingra S, et al. Antibiotic use in low and middle-income countries and the challenges of antimicrobial resistance in surgery. Antibiotics (Basel). 2020;9(8):497. doi: 10.3390/antibiotics9080497.

Frenette C, Sperlea D, German GJ, Afra K, Boswell J, Chang S, et al. The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals. Antimicrob Resist Infect Control. 2020;9(1):104. doi: 10.1186/s13756-020-00758-x.

Vandael E, Latour K, Goossens H, Magerman K, Drapier N, Catry B, et al. Point prevalence survey of antimicrobial use and healthcare-associated infections in Belgian acute care hospitals: results of the Global-PPS and ECDC-PPS 2017. Antimicrob Resist Infect Control. 2020;9(1):13. doi: 10.1186/s13756-019-0663-7.

Fowotade A, Fasuyi T, Aigbovo O, Versporten A, Adekanmbi O, Akinyemi O, et al. Point prevalence survey of antimicrobial prescribing in a Nigerian hospital: Findings and implications on antimicrobial resistance. West Afr J Med. 2020;37(3):216-220. PMID: 32476113.

Harun MGD, Sumon SA, Hasan I, Akther FM, Islam MS, Anwar MMU. Barriers, facilitators, perceptions and impact of interventions in implementing antimicrobial stewardship programs in hospitals of low-middle and middle countries: a scoping review. Antimicrob Resist Infect Control. 2024;13(1):8. doi: 10.1186/s13756-024-01369-6.

Altaf U, Saleem Z, Akhtar MF, Altowayan WM, Alqasoumi AA, Alshammari MS, et al. Using culture sensitivity reports to optimize antimicrobial therapy: Findings and implications of antimicrobial stewardship activity in a hospital in Pakistan. Medicina. 2023;59(7):1237. doi: 10.3390/medicina59071237.

Korinteli IG, McHedlishvili I, Javakhadze M, Versporten A, Goossens H, Phagava H, et al. The global point prevalence survey (PPS) of antimicrobial use among hospitalized children in Georgia. Georgian Med News. 2019(292-293):72-75. PMID: 31560667.

Enimil A, Agbedinu K, Yeboah M, Pauwels I, Goossens H, Ansong D, et al. Comparing patterns in antimicrobial use during global point prevalence study at a single tertiary hospital in Ghana: Implications for antimicrobial stewardship program. Front Trop Dis. 2022;3. doi: 10.3389/fitd.2022.843509.

Booth LD, Sick-Samuels AC, Milstone AM, Fackler JC, Gnazzo LK, Stockwell DC. Culture ordering for patients with new-onset fever: A survey of pediatric intensive care unit clinician practices. Pediatr Qual Saf. 2021;6(5):e463. doi: 10.1097/pq9.0000000000000463.

Kothari RD, Barde A, Bhide H, Deshpande T, Narkar NS, Tilak A. Use of cephalosporin type antimicrobials in infection wards in tertiary hospital in West India. J Pharm Res Int. 2021;33(43B):510-517. doi: 10.9734/jpri/2021/v33i43B32582.

Nath A, Balasubramanian A, Ramalingam K. Cephalosporins: An imperative antibiotic over the generations. Int J Res Pharm Sci. 2020;11(1):623-629.

McCarthy K, Avent M. Oral or intravenous antibiotics? Australian Prescriber. 2020;43(2):45-48. doi: 10.18773/austprescr.2020.008.

Garwan YM, Alsalloum MA, Thabit AK, Jose J, Eljaaly K. Effectiveness of antimicrobial stewardship interventions on early switch from intravenous-to-oral antimicrobials in hospitalized adults: A systematic review. Am J Infect Control. 2023;51(1):89-98. doi: 10.1016/j.ajic.2022.05.017.

Harvey EJ, Hand K, Weston D, Ashiru-Oredope D. Development of national antimicrobial intravenous-to-oral switch criteria and decision aid. J Clin Med. 2023;12(6). doi: 10.3390/jcm12062086.

Shrayteh ZM, Rahal MK, Malaeb DN. Practice of switch from intravenous to oral antibiotics. SpringerPlus. 2014;3:717. doi: 10.1186/2193-1801-3-717.

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Published

2024-09-07

How to Cite

Kurmanji, J. M., See, O. G., Al- Jumaili, A. A., & Younus, M. M. (2024). Quality Indicators of Antimicrobials Prescribing in Iraq: A Scoping Review. Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), 7(1), 221–226. https://doi.org/10.54133/ajms.v7i1.1227

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Review article

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