The Impact of Serum and Follicular Fluid Irisin on Oocyte and Embryonic Characteristics in Infertile Women Undergoing ICSI According to BMI
DOI:
https://doi.org/10.54133/ajms.v5i.224Keywords:
Infertility, Obesity, Irisin, Intracytoplasmic sperm injection, Oocyte and embryo characteristicsAbstract
Background: Irisin is a recently identified myokine that acts like adipokines. It has been revealed to be connected with insulin resistance (IR), obesity, and metabolic syndrome. Objective: To investigate serum, follicular fluid (FF), irisin, and IR in lean, overweight, and obese women undergoing the intracytoplasmic sperm injection (ICSI) cycle and correlate them with oocyte and embryo quality. Methods: Ninety infertile Iraqi women aged 18 to 40 years had primary or secondary infertility. They were enrolled in this study and divided into three groups according to body mass index ranking: the first group: twenty-seven normal-weight females, the second group: thirty-five overweight females, and the third group: twenty-eight obese females. ICSI was done for them to evaluate the level of serum and follicular fluid Irisin with the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) at the day of oocyte pickup and correlate them to the outcome. Results: HOMI-IR, serum, and FF Irisin levels were significantly higher in obese people. Also, there was a significant difference between groups in regard to MII, oocyte maturity rate, grade 1 embryo, and pregnancy outcome, which was less in the obese group. In addition, there was a significant negative correlation between HOMI-IR and irisin levels in serum and follicular fluid with MII oocyte count, oocyte maturity rate, embryo grade 1, and pregnancy outcome. Conclusion: Serum, follicular fluid Irisin, and HOMA-IR were significantly higher in obese cases than in lean cases, which may cause a reduction in the ICSI outcome.
Downloads
References
Zhou L, Li C, Liu X, Zhang T. Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure. Reprod Biol Endocrinol. 2021;19(1):1-7. doi:10.1186/s12958-021-00700-9. DOI: https://doi.org/10.1186/s12958-021-00700-9
Ulualan G, Kiraz ZK, Kırel B. Relation of serum irisin levels to obesity and non-alcoholic fatty liver disease. Turk J Pediatr. 2022;64(2):246. doi:10.24953/turkjped.2020.3003.
Ibrahim MH, Ahmed SA, Abdel Moety DA, Elsayed SF. The relation of serum irisin level with metabolic and hormonal changes in rat model of polycystic ovary. Zagazig Univ Med J. 2018;24(5):409-419. doi :10.21608/ZUMJ.2018.13266. DOI: https://doi.org/10.21608/zumj.2018.13266
Majorczyk M, Staszkiewicz M, Szklarczyk J, Major P, Pisarska M, Wysocki M, et al. The influence of bariatric surgery on serum levels of irisin and nesfatin-1. Acta Chir Belg. 2019;119(6):363-369. doi: 10.1080/00015458.2018.1534393. DOI: https://doi.org/10.1080/00015458.2018.1534393
Liu R, Shi L, Peng N, Zhang Q, Li H. Higher baseline serum irisin decreases risk for body mass index increment in Chinese populations: A 3.2-year cohort study. Diabetes Ther. 2019;10(2):713. doi:10.1007/S13300-019-0588-4. DOI: https://doi.org/10.1007/s13300-019-0588-4
Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018;16(1):1-13. doi: 10.1186/S12958-018-0336-z/figures/3. DOI: https://doi.org/10.1186/s12958-018-0336-z
Nelson OE, Chukwuma EF. Association of body mass index with hypothalamus-pituitary-ovarian axis hormones in infertile women in the Niger Delta region, Nigeria. Open J Obstet Gynecol. 2022;12(08):671-685. doi:10.4236/ojog.2022.1280608. DOI: https://doi.org/10.4236/ojog.2022.128060
Al-Yasiry RZ, Jwad MA, Hasan MF, Alsayigh HA. How obesity affects female fertility. Med J Babylon. 2022;19(2):111-114. doi:10.4103/mjbl.mjbl_8_22. DOI: https://doi.org/10.4103/MJBL.MJBL_8_22
Hussam F, Khudair SA, Alkhafaje WK, Alnassar YS, Kaoud RM, Abed AN, et al. A cross-sectional study regarding infertility among women in Iraq. J Obstet Gynecol Cancer Res. 2023;8(1):47–52. doi: 10.30699/jogcr.8.1.47. DOI: https://doi.org/10.30699/jogcr.8.1.47
World Obesity. Obesity Classification [Internet]. Obesity Classification. 2022 [cited 2023 Sep 4]. Available from: https://www.worldobesity.org/about/about-obesity/obesity-classification
Balaban B, Brison D, Calderón G, Catt J, Conaghan J, Cowan L, et al. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26(6):1270-1283. doi: 10.1093/humrep/der037. DOI: https://doi.org/10.1093/humrep/der037
Matthews DR, Hosker JR, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and fl-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419. doi: 10.1007/BF00280883. DOI: https://doi.org/10.1007/BF00280883
Pengpid S, Peltzer K. Overweight and obesity among adults in Iraq: Prevalence and correlates from a national survey in 2015. Int J Environ Res Public Health. 2021;18:4198. doi: 10.3390/ijerph18084198. DOI: https://doi.org/10.3390/ijerph18084198
Gautam D, Purandare N, Maxwell C V., Rosser ML, O’Brien P, Mocanu E, et al. The challenges of obesity for fertility: A FIGO literature review. Int J Gynecol Obstet. 2023;160(S1):50-55. doi: 10.1002/ijgo.14538. DOI: https://doi.org/10.1002/ijgo.14538
Pandey S, Pandey S, Maheshwari A, Bhattacharya S. The impact of female obesity on the outcome of fertility treatment. J Hum Reprod Sci. 2010;3(2):62. doi: 10.4103/0974-1208.69332. DOI: https://doi.org/10.4103/0974-1208.69332
Stimulation TEGG on O, Bosch E, Broer S, Griesinger G, Grynberg M, Humaidan P, et al. ESHRE guideline: ovarian stimulation for IVF/ICSI†. Hum Reprod Open. 2020;2020(2): hoaa009. doi: 10.1093/hropen/hoaa009. DOI: https://doi.org/10.1093/hropen/hoaa009
Pan XM, Lin Z, Li N, Wu JQ, Chen DQ, Zhu YM, et al. Effects of body mass index on the outcomes of in vitro fertilization in Chinese patients with polycystic ovary syndrome: a retrospective cohort study. J Zhejiang Univ Sci B. 2018;19(6):490-496. doi: 10.1631/jzus.B1800113. DOI: https://doi.org/10.1631/jzus.B1800113
Ozekinci M, Seven A, Olgan S, Sakinci M, Keskin U, Akar ME, et al. Does obesity have detrimental effects on IVF treatment outcomes? BMC Womens Health. 2015;15(1):1-7. doi: 10.1186/s12905-015-0223-0. DOI: https://doi.org/10.1186/s12905-015-0223-0
Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, et al. Overweight, obesity and assisted reproduction: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2022;271:117-127. doi: 10.1016/j.ejogrb.2022.01.019. DOI: https://doi.org/10.1016/j.ejogrb.2022.01.019
Dornelles VC, Hentschke MR, Badalotti M, Telöken IB, Trindade VD, Cunegatto B, et al. The impact of body mass index on laboratory, clinical outcomes and treatment costs in assisted reproduction: a retrospective cohort study. BMC Women Health. 2022;22(1):1-8. doi: 10.1186/s12905-022-02036-x. DOI: https://doi.org/10.1186/s12905-022-02036-x
Masschelin PM, Cox AR, Chernis N, Hartig SM. The impact of oxidative stress on adipose tissue energy balance. Front Physiol. 2020;10:1638. doi: 10.3389/fphys.2019.01638. DOI: https://doi.org/10.3389/fphys.2019.01638
Sharan B, Sagili H, Kamalanathan SK, Lakshminarayanan S. Serum irisin levels and its association with blood glucose and insulin indices in diagnosing insulin resistance in adolescents with polycystic ovarian syndrome. J Hum Reprod Sci. 2021;14(2):137-143. doi: 10.4103/jhrs.jhrs_191_20. DOI: https://doi.org/10.4103/jhrs.jhrs_191_20
Kruszewska J, Laudy-Wiaderny H, Kunicki M. Review of novel potential insulin resistance biomarkers in PCOS patients: The debate is still open. Int J Environ Res Public Health. 2022;19:2099. doi: 10.3390/ijerph19042099. DOI: https://doi.org/10.3390/ijerph19042099
Furino VO, Alves JM, Marine DA, Sene-Fiorese M, Rodrigues CNDS, Arrais-Lima C, et al. Front Physiol. 2021;12:564963. doi: 10.3389/fphys.2021.564963. DOI: https://doi.org/10.3389/fphys.2021.564963
Park SY, Gautier JF, Chon S. Assessment of insulin secretion and insulin resistance in human. Diabetes Metab J. 2021;45(5):641. doi: 10.4093/dmj.2021.0220. DOI: https://doi.org/10.4093/dmj.2021.0220
Bahadur A, Verma N, Mundhra R, Chawla L, Ajmani M, Sri MS, et al. Correlation of homeostatic model assessment-insulin resistance, anti-mullerian hormone, and BMI in the characterization of polycystic ovary syndrome. Cureus. 2021;13(6):e16047. doi: 10.7759/cureus.16047. DOI: https://doi.org/10.7759/cureus.16047
Chen W, Pang Y, Hill JW, Meikle P. Metabolic syndrome and PCOS: Pathogenesis and the role of metabolites. Metabolites. 2021;11(12):869. doi: 10.3390/metabo11120869. DOI: https://doi.org/10.3390/metabo11120869
Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab. 2013;98(4):E769-778. doi: 10.1210/jc.2012-2749. DOI: https://doi.org/10.1210/jc.2012-2749
Tang L, Tong Y, Zhang F, Chen G, Zhang YC, Jobin J, et al. The association of circulating irisin with metabolic risk factors in Chinese adults: A cross-sectional community-based study. BMC Endocr Disord. 2019;19(1):1-6. doi: 10.1186/s12902-019-0479-8. DOI: https://doi.org/10.1186/s12902-019-0479-8
Mai S, Grugni G, Mele C, Vietti R, Vigna L, Sartorio A, et al. Irisin levels in genetic and essential obesity: clues for a potential dual role. Sci Rep. 2020 Jan 23;10(1):1020. doi: 10.1038/s41598-020-57855-5. DOI: https://doi.org/10.1038/s41598-020-57855-5
Al-Ghazali MJ, Ali HA, Al-Rufaie MM. Serum irisin levels as a potential marker for diagnosis of gestational diabetes mellitus. Acta Biomed. 2020;91(1):56-63. doi: 10.23750/abm.v91i1.7675.
Leustean L, Preda C, Teodoriu L, Mihalache L, Arhire L, Ungureanu MC. Role of irisin in endocrine and metabolic disorders—Possible new therapeutic agent? Appl Sci. 2021;11(12):5579. doi: 10.3390/app11125579. DOI: https://doi.org/10.3390/app11125579
Sengupta P, Dutta S, Karkada IR, Akhigbe RE, Chinni S V. Irisin, energy homeostasis and male reproduction. Front Physiol. 2021;12:746049. doi: 10.3389/fphys.2021.746049. DOI: https://doi.org/10.3389/fphys.2021.746049
Campbell M, Jialal I. Physiology, Endocrine Hormones, In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.
Arhire LI, Mihalache L, Covasa M. Irisin: A hope in understanding and managing obesity and metabolic syndrome. Front Endocrinol (Lausanne). 2019;10:524. doi: 10.3389/fendo.2019.00524. DOI: https://doi.org/10.3389/fendo.2019.00524
De Meneck F, Victorino de Souza L, Oliveira V, do Franco MC. High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells. Nutr Metab Cardiovasc Dis. 2018;28(7):756-764. doi: 10.1016/j.numecd.2018.04.009. DOI: https://doi.org/10.1016/j.numecd.2018.04.009
Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index. Peptides. 2013;39(1):125-130. doi: 10.1016/j.peptides.2012.11.014. DOI: https://doi.org/10.1016/j.peptides.2012.11.014
Palacios-González B, Vadillo-Ortega F, Polo-Oteyza E, Sánchez T, Ancira-Moreno M, Romero-Hidalgo S, et al. Irisin levels before and after physical activity among school-age children with different BMI: A direct relation with leptin. Obesity. 2015;23(4):729-732. doi: 10.1002/oby.21029. DOI: https://doi.org/10.1002/oby.21029
Ulualan G, Kiraz ZK, Kırel B. Relation of serum irisin levels to obesity and non-alcoholic fatty liver disease. Turk J Pediatr. 2022;64(2):246-254. doi: 10.24953/turkjped.2020.3003. DOI: https://doi.org/10.24953/turkjped.2020.3003
Gonzalez-Gil AM, Peschard-Franco M, Castillo EC, Gutierrez-Delbosque G, Treviño V, Silva-Platas C, et al. Myokine-adipokine cross-talk: Potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome. Diabetol Metab Syndr. 2019;11(1):1-16. doi: 10.1186/s13098-019-0458-2. DOI: https://doi.org/10.1186/s13098-019-0458-2
Bousmpoula A, Benidis E, Demeridou S, Kapeta-Kourkouli R, Chasiakou A, Chasiakou S, et al. Serum and follicular fluid irisin levels in women with polycystic ovaries undergoing ovarian stimulation: correlation with insulin resistance and lipoprotein lipid profiles. Gynecol Endocrinol. 2019;35(9):803-806. doi: 10.1080/09513590.2019.1594761. DOI: https://doi.org/10.1080/09513590.2019.1594761
Zhang R, Fu T, Zhao X, Qiu Y, Hu X, Shi H, et al. Association of circulating irisin levels with adiposity and glucose metabolic profiles in a middle-aged Chinese population: A cross-sectional study. Diabetes, Metab Syndr Obes Targets Ther. 2020;13:4105-4112. doi: 10.2147/DMSO.S275878. DOI: https://doi.org/10.2147/DMSO.S275878
Sun B, Ma Y, Li L, Hu L, Wang F, Zhang Y, et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) severity in women with polycystic ovary syndrome undergoing IVF/ICSI. Front Endocrinol (Lausanne). 2021;11:1. doi: 10.3389/fendo.2020.615957. DOI: https://doi.org/10.3389/fendo.2020.615957
Brinca AT, Ramalhinho AC, Sousa Â, Oliani AH, Breitenfeld L, Passarinha LA, et al. Follicular fluid: A powerful tool for the understanding and diagnosis of polycystic ovary syndrome. Biomedicines. 2022;10(6):1254. doi: 10.3390/biomedicines10061254. DOI: https://doi.org/10.3390/biomedicines10061254

Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 )

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Published by Al-Rafidain University College. This is an open access journal issued under the CC BY-NC-SA 4.0 license (https://creativecommons.org/licenses/by-nc-sa/4.0/).