The Impact of Serum and Follicular Fluid Irisin on Oocyte and Embryonic Characteristics in Infertile Women Undergoing ICSI According to BMI

Zhou L, Li C, Liu X, Zhang T. Effect of Irisin on LIF and integrin αvβ3 in rats of implantation failure. Reprod Biol Endocrinol. 2021;19(1):1-7. doi:10.1186/s12958-021-00700-9.

Ulualan G, Kiraz ZK, Kırel B. Relation of serum irisin levels to obesity and non-alcoholic fatty liver disease. Turk J Pediatr. 2022;64(2):246. doi:10.24953/turkjped.2020.3003.

Ibrahim MH, Ahmed SA, Abdel Moety DA, Elsayed SF. The relation of serum irisin level with metabolic and hormonal changes in rat model of polycystic ovary. Zagazig Univ Med J. 2018;24(5):409-419. doi :10.21608/ZUMJ.2018.13266.

Majorczyk M, Staszkiewicz M, Szklarczyk J, Major P, Pisarska M, Wysocki M, et al. The influence of bariatric surgery on serum levels of irisin and nesfatin-1. Acta Chir Belg. 2019;119(6):363-369. doi: 10.1080/00015458.2018.1534393.

Liu R, Shi L, Peng N, Zhang Q, Li H. Higher baseline serum irisin decreases risk for body mass index increment in Chinese populations: A 3.2-year cohort study. Diabetes Ther. 2019;10(2):713. doi:10.1007/S13300-019-0588-4.

Silvestris E, de Pergola G, Rosania R, Loverro G. Obesity as disruptor of the female fertility. Reprod Biol Endocrinol. 2018;16(1):1-13. doi: 10.1186/S12958-018-0336-z/figures/3.

Nelson OE, Chukwuma EF. Association of body mass index with hypothalamus-pituitary-ovarian axis hormones in infertile women in the Niger Delta region, Nigeria. Open J Obstet Gynecol. 2022;12(08):671-685. doi:10.4236/ojog.2022.1280608.

Al-Yasiry RZ, Jwad MA, Hasan MF, Alsayigh HA. How obesity affects female fertility. Med J Babylon. 2022;19(2):111-114. doi:10.4103/mjbl.mjbl_8_22.

Hussam F, Khudair SA, Alkhafaje WK, Alnassar YS, Kaoud RM, Abed AN, et al. A cross-sectional study regarding infertility among women in Iraq. J Obstet Gynecol Cancer Res. 2023;8(1):47–52. doi: 10.30699/jogcr.8.1.47.

World Obesity. Obesity Classification [Internet]. Obesity Classification. 2022 [cited 2023 Sep 4]. Available from: https://www.worldobesity.org/about/about-obesity/obesity-classification

Balaban B, Brison D, Calderón G, Catt J, Conaghan J, Cowan L, et al. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26(6):1270-1283. doi: 10.1093/humrep/der037.

Matthews DR, Hosker JR, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and fl-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-419. doi: 10.1007/BF00280883.

Pengpid S, Peltzer K. Overweight and obesity among adults in Iraq: Prevalence and correlates from a national survey in 2015. Int J Environ Res Public Health. 2021;18:4198. doi: 10.3390/ijerph18084198.

Gautam D, Purandare N, Maxwell C V., Rosser ML, O’Brien P, Mocanu E, et al. The challenges of obesity for fertility: A FIGO literature review. Int J Gynecol Obstet. 2023;160(S1):50-55. doi: 10.1002/ijgo.14538.

Pandey S, Pandey S, Maheshwari A, Bhattacharya S. The impact of female obesity on the outcome of fertility treatment. J Hum Reprod Sci. 2010;3(2):62. doi: 10.4103/0974-1208.69332.

Stimulation TEGG on O, Bosch E, Broer S, Griesinger G, Grynberg M, Humaidan P, et al. ESHRE guideline: ovarian stimulation for IVF/ICSI†. Hum Reprod Open. 2020;2020(2): hoaa009. doi: 10.1093/hropen/hoaa009.

Pan XM, Lin Z, Li N, Wu JQ, Chen DQ, Zhu YM, et al. Effects of body mass index on the outcomes of in vitro fertilization in Chinese patients with polycystic ovary syndrome: a retrospective cohort study. J Zhejiang Univ Sci B. 2018;19(6):490-496. doi: 10.1631/jzus.B1800113.

Ozekinci M, Seven A, Olgan S, Sakinci M, Keskin U, Akar ME, et al. Does obesity have detrimental effects on IVF treatment outcomes? BMC Womens Health. 2015;15(1):1-7. doi: 10.1186/s12905-015-0223-0.

Ribeiro LM, Sasaki LMP, Silva AA, Souza ES, Oliveira Lyrio A, et al. Overweight, obesity and assisted reproduction: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2022;271:117-127. doi: 10.1016/j.ejogrb.2022.01.019.

Dornelles VC, Hentschke MR, Badalotti M, Telöken IB, Trindade VD, Cunegatto B, et al. The impact of body mass index on laboratory, clinical outcomes and treatment costs in assisted reproduction: a retrospective cohort study. BMC Women Health. 2022;22(1):1-8. doi: 10.1186/s12905-022-02036-x.

Masschelin PM, Cox AR, Chernis N, Hartig SM. The impact of oxidative stress on adipose tissue energy balance. Front Physiol. 2020;10:1638. doi: 10.3389/fphys.2019.01638.

Sharan B, Sagili H, Kamalanathan SK, Lakshminarayanan S. Serum irisin levels and its association with blood glucose and insulin indices in diagnosing insulin resistance in adolescents with polycystic ovarian syndrome. J Hum Reprod Sci. 2021;14(2):137-143. doi: 10.4103/jhrs.jhrs_191_20.

Kruszewska J, Laudy-Wiaderny H, Kunicki M. Review of novel potential insulin resistance biomarkers in PCOS patients: The debate is still open. Int J Environ Res Public Health. 2022;19:2099. doi: 10.3390/ijerph19042099.

Furino VO, Alves JM, Marine DA, Sene-Fiorese M, Rodrigues CNDS, Arrais-Lima C, et al. Front Physiol. 2021;12:564963. doi: 10.3389/fphys.2021.564963.

Park SY, Gautier JF, Chon S. Assessment of insulin secretion and insulin resistance in human. Diabetes Metab J. 2021;45(5):641. doi: 10.4093/dmj.2021.0220.

Bahadur A, Verma N, Mundhra R, Chawla L, Ajmani M, Sri MS, et al. Correlation of homeostatic model assessment-insulin resistance, anti-mullerian hormone, and BMI in the characterization of polycystic ovary syndrome. Cureus. 2021;13(6):e16047. doi: 10.7759/cureus.16047.

Chen W, Pang Y, Hill JW, Meikle P. Metabolic syndrome and PCOS: Pathogenesis and the role of metabolites. Metabolites. 2021;11(12):869. doi: 10.3390/metabo11120869.

Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab. 2013;98(4):E769-778. doi: 10.1210/jc.2012-2749.

Tang L, Tong Y, Zhang F, Chen G, Zhang YC, Jobin J, et al. The association of circulating irisin with metabolic risk factors in Chinese adults: A cross-sectional community-based study. BMC Endocr Disord. 2019;19(1):1-6. doi: 10.1186/s12902-019-0479-8.

Mai S, Grugni G, Mele C, Vietti R, Vigna L, Sartorio A, et al. Irisin levels in genetic and essential obesity: clues for a potential dual role. Sci Rep. 2020 Jan 23;10(1):1020. doi: 10.1038/s41598-020-57855-5.

Al-Ghazali MJ, Ali HA, Al-Rufaie MM. Serum irisin levels as a potential marker for diagnosis of gestational diabetes mellitus. Acta Biomed. 2020;91(1):56-63. doi: 10.23750/abm.v91i1.7675.

Leustean L, Preda C, Teodoriu L, Mihalache L, Arhire L, Ungureanu MC. Role of irisin in endocrine and metabolic disorders—Possible new therapeutic agent? Appl Sci. 2021;11(12):5579. doi: 10.3390/app11125579.

Sengupta P, Dutta S, Karkada IR, Akhigbe RE, Chinni S V. Irisin, energy homeostasis and male reproduction. Front Physiol. 2021;12:746049. doi: 10.3389/fphys.2021.746049.

Campbell M, Jialal I. Physiology, Endocrine Hormones, In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.

Arhire LI, Mihalache L, Covasa M. Irisin: A hope in understanding and managing obesity and metabolic syndrome. Front Endocrinol (Lausanne). 2019;10:524. doi: 10.3389/fendo.2019.00524.

De Meneck F, Victorino de Souza L, Oliveira V, do Franco MC. High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells. Nutr Metab Cardiovasc Dis. 2018;28(7):756-764. doi: 10.1016/j.numecd.2018.04.009.

Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity – Correlation with body mass index. Peptides. 2013;39(1):125-130. doi: 10.1016/j.peptides.2012.11.014.

Palacios-González B, Vadillo-Ortega F, Polo-Oteyza E, Sánchez T, Ancira-Moreno M, Romero-Hidalgo S, et al. Irisin levels before and after physical activity among school-age children with different BMI: A direct relation with leptin. Obesity. 2015;23(4):729-732. doi: 10.1002/oby.21029.

Ulualan G, Kiraz ZK, Kırel B. Relation of serum irisin levels to obesity and non-alcoholic fatty liver disease. Turk J Pediatr. 2022;64(2):246-254. doi: 10.24953/turkjped.2020.3003.

Gonzalez-Gil AM, Peschard-Franco M, Castillo EC, Gutierrez-Delbosque G, Treviño V, Silva-Platas C, et al. Myokine-adipokine cross-talk: Potential mechanisms for the association between plasma irisin and adipokines and cardiometabolic risk factors in Mexican children with obesity and the metabolic syndrome. Diabetol Metab Syndr. 2019;11(1):1-16. doi: 10.1186/s13098-019-0458-2.

Bousmpoula A, Benidis E, Demeridou S, Kapeta-Kourkouli R, Chasiakou A, Chasiakou S, et al. Serum and follicular fluid irisin levels in women with polycystic ovaries undergoing ovarian stimulation: correlation with insulin resistance and lipoprotein lipid profiles. Gynecol Endocrinol. 2019;35(9):803-806. doi: 10.1080/09513590.2019.1594761.

Zhang R, Fu T, Zhao X, Qiu Y, Hu X, Shi H, et al. Association of circulating irisin levels with adiposity and glucose metabolic profiles in a middle-aged Chinese population: A cross-sectional study. Diabetes, Metab Syndr Obes Targets Ther. 2020;13:4105-4112. doi: 10.2147/DMSO.S275878.

Sun B, Ma Y, Li L, Hu L, Wang F, Zhang Y, et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) severity in women with polycystic ovary syndrome undergoing IVF/ICSI. Front Endocrinol (Lausanne). 2021;11:1. doi: 10.3389/fendo.2020.615957.

Brinca AT, Ramalhinho AC, Sousa Â, Oliani AH, Breitenfeld L, Passarinha LA, et al. Follicular fluid: A powerful tool for the understanding and diagnosis of polycystic ovary syndrome. Biomedicines. 2022;10(6):1254. doi: 10.3390/biomedicines10061254.