Parathyroid Hormone Enhances Primary Stability of Dental Implants and Radiographic Analysis: Randomized, Split-Mouth Clinical Trial

Authors

  • Enas Nihad Mohammed Department of Periodontology, College of Dentistry, University of Baghdad, Baghdad, Iraq https://orcid.org/0009-0000-7921-6581
  • Hassanien Ahmad Al-Jumaily Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Baghdad, Baghdad, Iraq

DOI:

https://doi.org/10.54133/ajms.v8i1.1413

Keywords:

CBCT imaging, Parathyroid hormone, Socket preservation, Tooth extraction

Abstract

Background: Dental implants are a highly effective treatment in modern dentistry and are employed when enough high-quality bones are available to give optimal support and long-term success in restoring function. No material meets all the criteria to be considered the ideal graft. Parathyroid hormone, specifically PTH1-34, offers a promising and efficient approach to enhancing bone regeneration. Objective: To evaluate the effect of PTH with bone graft on socket preservation in radiographical assessment and primary stability of the implant. Methods: This study included 16 patients with 32 sockets; 16 received xenograft only, and 16 received xenograft with PTH after tooth extraction. The bone height and width of the socket were measured after extraction and before placing the implant using cone beam computed tomography (CBCT). The implant stability was measured using Osstell® (ISQ) and was recorded immediately. Results: After a 4-month follow-up period, the reduction of buccal bone height (BBH), labial bone height (LBH), and horizontal bone width (HBW) between the group of bone grafts only, and the bone graft with PTH group was statistically non-significant. Additionally, highly significant primary stability in the PTH group. Conclusions: The use of xenograft and PTH (1–34) can enhance the primary stability of the implant and recovery of cortical and cancellous bone surrounding dental implants.

Downloads

Download data is not yet available.

References

Juodzbalys G, Stumbras A, Goyushov S, Duruel O, Tözüm TF. Morphological classification of extraction sockets and clinical decision tree for socket preservation/augmentation after tooth extraction: A systematic review. J Oral Maxillofac Res. 2019;10(3):e3. doi: 10.5037/jomr.2019.10303. DOI: https://doi.org/10.5037/jomr.2019.10303

Troiano G, Zhurakivska K, Lo Muzio L, Laino L, Cicciù M, Lo Russo L. Combination of bone graft and resorbable membrane for alveolar ridge preservation: A systematic review, meta-analysis, and trial sequential analysis. J Periodontol. 2018;89(1):46-57. doi: 10.1902/jop.2017.170241. DOI: https://doi.org/10.1902/jop.2017.170241

Pohl V, Fürhauser L, Haas R, Pohl S. Gingival recession behavior with immediate implant placement in the anterior maxilla with buccal dehiscence without additional augmentation-a pilot study. Clin Oral Investig. 2020;24(4):1455-1464. doi: 10.1007/s00784-019-03176-5. DOI: https://doi.org/10.1007/s00784-019-03176-5

Ramanauskaite A, Borges T, Almeida BL, Correia A. Dental implant outcomes in grafted sockets: A systematic review and meta-analysis. J Oral Maxillofac Res. 2019;10(3):e8. doi: 10.5037/jomr.2019.10308. DOI: https://doi.org/10.5037/jomr.2019.10308

Karim OK, Fatah AA. Assessment of dental implant site dimensions and alveolar bone density in the mandible using cone beam computed tomography. J Bagh Coll Dent. 2018;30(2):34-40. DOI: https://doi.org/10.12816/0049749

Lyu C, Shao Z, Zou D, Lu J. Ridge alterations following socket preservation using a collagen membrane in dogs. Biomed Res Int. 2020;2020:1487681. doi: 10.1155/2020/1487681. DOI: https://doi.org/10.1155/2020/1487681

Stumbras A, Kuliesius P, Januzis G, Juodzbalys G. Alveolar ridge preservation after tooth extraction using different bone graft materials and autologous platelet concentrates: A systematic review. J Oral Maxillofac Res. 2019;10(1):e2. doi: 10.5037/jomr.2019.10102. DOI: https://doi.org/10.5037/jomr.2019.10102

Aspenberg P, Genant HK, Johansson T, Nino AJ, See K, Krohn K, et al. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res. 2010;25(2):404-414. doi: 10.1359/jbmr.090731. DOI: https://doi.org/10.1359/jbmr.090731

Kuroshima S, Al-Salihi Z, Yamashita J. Parathyroid hormone related to bone regeneration in grafted and nongrafted tooth extraction sockets in rats. Implant Dent. 2013;22(1):71-76. doi: 10.1097/ID.0b013e318278f94d. DOI: https://doi.org/10.1097/ID.0b013e318278f94d

Silva BC, Bilezikian JP. Parathyroid hormone: anabolic and catabolic actions on the skeleton. Curr Opin Pharmacol. 2015;22:41-50. doi: 10.1016/j.coph.2015.03.005. DOI: https://doi.org/10.1016/j.coph.2015.03.005

Chen H, Fu T, Ma Y, Wu X, Li X, Li X, et al. Intermittent administration of parathyroid hormone ameliorated alveolar bone loss in experimental periodontitis in streptozotocin-induced diabetic rats. Arch Oral Biol. 2017;83:76-84. doi: 10.1016/j.archoralbio.2017.06.033. DOI: https://doi.org/10.1016/j.archoralbio.2017.06.033

Choudhary S, Canalis E, Estus T, Adams D, Pilbeam C. Cyclooxygenase-2 suppresses the anabolic response to PTH infusion in mice. PLoS One. 2015;10(3):e0120164. doi: 10.1371/journal.pone.0120164. DOI: https://doi.org/10.1371/journal.pone.0120164

Elfana A, El-Kholy S, Saleh HA, Fawzy El-Sayed K. Alveolar ridge preservation using autogenous whole-tooth versus demineralized dentin grafts: A randomized controlled clinical trial. Clin Oral Implants Res. 2021;32(5):539-548. doi: 10.1111/clr.13722. DOI: https://doi.org/10.1111/clr.13722

Frigério PB, Gomes-Ferreira PHS, de Souza Batista FR, Moura J, Rangel Garcia Júnior I, Botticelli D, et al. Effect of topical PTH 1-34 functionalized to Biogran® in the process of alveolar repair in rats submitted to orchiectomy. Materials (Basel). 2021;15(1):207. doi: 10.3390/ma15010207. DOI: https://doi.org/10.3390/ma15010207

Horváth A, Mardas N, Mezzomo LA, Needleman IG, Donos N. Alveolar ridge preservation. A systematic review. Clin Oral Investig. 2013 Mar;17(2):341-63. doi: 10.1007/s00784-012-0758-5. Epub 2012 Jul 20. PMID: 22814758. DOI: https://doi.org/10.1007/s00784-012-0758-5

Al-Quisi AF, Mohammed Aldaghir O, Al-Jumaily HA. Comparison between rolled and nonrolled U-shaped flap in the second stage of dental implant surgery: A randomized clinical trial. Int J Dent. 2022;2022:1329468. doi: 10.1155/2022/1329468. DOI: https://doi.org/10.1155/2022/1329468

Emam H, Leach D, Sun Z, Tee BC, Karatas B, Kim DG, et al. The effect of parathyroid hormone analogues when added to mineralized bone xenografts. J Oral Implantol. 2020;46(4):372-379. doi: 10.1563/aaid-joi-D-19-00016. DOI: https://doi.org/10.1563/aaid-joi-D-19-00016

Kuroshima S, Kovacic BL, Kozloff KM, McCauley LK, Yamashita J. Intra-oral PTH administration promotes tooth extraction socket healing. J Dent Res. 2013;92(6):553-559. doi: 10.1177/0022034513487558. DOI: https://doi.org/10.1177/0022034513487558

Kim JH, Kim AR, Choi YH, Kim A, Sohn Y, Woo GH, et al. Intermittent PTH administration improves alveolar bone formation in type 1 diabetic rats with periodontitis. J Translat Med. 2018;16(1):70. doi: 10.1186/s12967-018-1438-2. DOI: https://doi.org/10.1186/s12967-018-1438-2

Rocha T, Cavalcanti AS, Leal AC, Dias RB, da Costa R., Ribeiro GO, et al. PTH1-34 improves devitalized allogenic bone graft healing in a murine femoral critical size defect. Injury. 2021;52(Suppl 3):S3–S12. doi: 10.1016/j.injury.2021.03.063. DOI: https://doi.org/10.1016/j.injury.2021.03.063

Xu L, Mei L, Zhao R, Yi J, Jiang Y, Li R, et al. The effects of intro-oral parathyroid hormone on the healing of tooth extraction socket: an experimental study on hyperglycemic rats. J Appl Oral Sci. 2020;28:e20190690. doi: 10.1590/1678-7757-2019-0690. DOI: https://doi.org/10.1590/1678-7757-2019-0690

Min S, Liu Y, Tang J, Xie Y, Xiong J, et al. Alveolar ridge dimensional changes following ridge preservation procedure with novel devices: Part 1--CBCT linear analysis in non-human primate model. Clin Oral Implant Res. 2016;27(1):97-105. doi: 10.1111/clr.12521. DOI: https://doi.org/10.1111/clr.12521

Araújo MG, da Silva JCC, de Mendonça AF, Lindhe J. (2015). Ridge alterations following grafting of fresh extraction sockets in man. A randomized clinical trial. Clin Oral Implant Res. 2015;26(4):407-412. doi: 10.1111/clr.12366. DOI: https://doi.org/10.1111/clr.12366

Wang RE, Lang NP. Ridge preservation after tooth extraction. Clin Oral Implant Res. 2012;23(Suppl 6)147-156. doi: 10.1111/j.1600-0501.2012.02560.x. DOI: https://doi.org/10.1111/j.1600-0501.2012.02560.x

Cardaropoli D, Tamagnone L, Roffredo A, Gaveglio L. (2014). Relationship between the buccal bone plate thickness and the healing of postextraction sockets with/without ridge preservation. Int J Periodont Restor Dent. 2014;34(2):211–217. doi: 10.11607/prd.1885. DOI: https://doi.org/10.11607/prd.1885

Noaman AT, Bede SY. The relationship of implant stability quotient and insertion torque in dental implant stability. J Baghdad Coll Dent. 2022;34(1):29-35. DOI: https://doi.org/10.26477/jbcd.v34i1.3089

Oki Y, Doi K, Makihara Y, Kobatake R, Kubo T, Tsuga K. Effects of continual intermittent administration of parathyroid hormone on implant stability in the presence of osteoporosis: an in vivo study using resonance frequency analysis in a rabbit model. J Appl Oral Sci. 2017;25(5):498–505. doi: 10.1590/1678-7757-2016-0561. DOI: https://doi.org/10.1590/1678-7757-2016-0561

Al-Rawi MO. Enhancement of osseointegration in dental implants through the use of parathyroid hormone (1-34) experimental study on rabbits. PhD dissertation, University of Baghdad, 2015.

Downloads

Published

2025-01-31

How to Cite

Mohammed, E. N., & Al-Jumaily , H. A. (2025). Parathyroid Hormone Enhances Primary Stability of Dental Implants and Radiographic Analysis: Randomized, Split-Mouth Clinical Trial. Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), 8(1), 32–37. https://doi.org/10.54133/ajms.v8i1.1413

Issue

Section

Original article

Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.