Is Maternal Aspirin Intake Truly Safe in The Long Run?

Henan Skheel Aljebory; Alexandru Cosmin Pantazi

doi:10.54133/ajms.v11i1.3155

Authors

Henan Skheel Aljebory Department of Obstetrics and Gynecology, College of Medicine, Mustansiriyah University, Baghdad, Iraq
Alexandru Cosmin Pantazi Department of Pediatrics, Faculty of Medicine, Ovidius University, 900470 Constanta, Romania https://orcid.org/0000-0002-7234-2814

DOI:

https://doi.org/10.54133/ajms.v11i1.3155

Keywords:

Low-dose aspirin, Long-term safety, Pregnancy, Preeclampsia, Recurrent pregnancy loss

Abstract

N/A

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References

ACOG Committee Opinion No. 743: Low-dose aspirin use during pregnancy. Obstet Gynecol. 2018;132(1):e44-e52. doi: 10.1097/AOG.0000000000002708. DOI: https://doi.org/10.1097/AOG.0000000000002708

van Limburg Stirum EV, van ’t Hooft J, Landman AJ, Finken MJ, Ravelli AC, Leemhuis AG, et al. Long‐term child outcomes after prenatal aspirin exposure: A 4‐year follow‐up of a randomized controlled trial (the APRIL study). Int J Gynecol Obstet. 2026;173(1):302-311. doi: 10.1002/ijgo.70581. DOI: https://doi.org/10.1002/ijgo.70581

Komoróczy B, Váncsa S, Váradi A, Hegyi P, Vágási V, Baradács I, et al. Optimal aspirin dosage for the prevention of pre-eclampsia and other adverse pregnancy outcomes: A systematic review and meta-analysis of randomized controlled trials. J Clin Med. 2025;14(7):2134. doi: 10.3390/jcm14072134. DOI: https://doi.org/10.3390/jcm14072134

Nori W, Shallal F, Zghair MA. Aspirin effect on mid luteal phase Doppler indices in patients with recurrent pregnancy loss. Int J Pharm Res. 2020;12(3):2929-2934. doi: 10.31838/ijpr/2020.12.03.413. DOI: https://doi.org/10.31838/ijpr/2020.12.03.413

Hoffman MK, Goudar S, Dhaded S, Figueroa L, Mazariegos M, Krebs NF, et al. Neurodevelopment of children whose mothers were randomized to low-dose aspirin during pregnancy. Obstet Gynecol. 2024;143(4):554-61. doi: 10.1097/aog.0000000000005514. DOI: https://doi.org/10.1097/AOG.0000000000005514

Mozaffari S, Mousavi T, Nikfar S, Abdollahi M. Common gastrointestinal drug-drug interactions in geriatrics and the importance of careful planning. Expert Opin Drug Metab Toxicol. 2023;19(11):807-828. doi: 10.1080/17425255.2023.2273384. DOI: https://doi.org/10.1080/17425255.2023.2273384

Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, et al. Aspirin use to prevent pre-eclampsia and related morbidity and mortality: US Preventive Services Task Force Recommendation Statement. JAMA. 2021;326(12):1186-1191. doi: 10.1001/jama.2021.14781. DOI: https://doi.org/10.1001/jama.2021.14781

Rodriguez-Sibaja MJ, Galvez-Rubalcava N, Hagerman-Sucar G, Alcocer-Gonzalez Camarena P, Gomez-Woodworth JR, Villalpando-Juarez MI, et al. Maternal, fetal, and neonatal serious adverse events associated with low-dose aspirin during the first trimester of pregnancy: A secondary analysis of the Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN) trial. Am J Obstet Gynecol MFM. 2025;7(11):101768. doi: 10.1016/j.ajogmf.2025.101768. DOI: https://doi.org/10.1016/j.ajogmf.2025.101768

Hoffman MK. Bridging the Gaps between Aspirin Guidelines and Pregnancy Outcomes. Delaware J Public Health. 2025;11(5):38. doi: 10.32481/djph.2025.12.07. DOI: https://doi.org/10.32481/djph.2025.12.07

Zhu J, Gan Y, Yang C, Gu W, Wang Y, Zhang J, et al. In utero aspirin exposure and child neurocognitive development: A propensity score‐matched analysis. BJOG. 2024;131(12):1630-1639. doi: 10.1111/1471-0528.17871. DOI: https://doi.org/10.1111/1471-0528.17871

Zhu J, Wang Y, Liu Z, Zhang J. Re-evaluating the impact of prenatal low-dose aspirin on child neurodevelopment. In: Seminars Perinatology. 2026 May 26 (p. 152256). WB Saunders. doi: 10.1016/j.semperi.2026.152256. DOI: https://doi.org/10.1016/j.semperi.2026.152256

Landman AJ, van Limburg Stirum EV, de Boer MA, van't Hooft J, Ket JC, Leemhuis AG, et al. Long-term health and neurodevelopment in children after antenatal exposure to low-dose aspirin for the prevention of pre-eclampsia and fetal growth restriction: a systematic review of randomized controlled trials. Eur J Obstet Gynecol Reprod Biol. 2021;267:213-220. doi: 10.1016/j.ejogrb.2021.11.010. DOI: https://doi.org/10.1016/j.ejogrb.2021.11.010

Swift EM, Guðnadóttir SA, Haraldsdóttir EH, Hjartardóttir H, Atladóttir LÓ, Helgadóttir H, et al. Adherence to aspirin use during pregnancy among women at risk of pre-eclampsia: A cross-sectional study. Acta Obstet Gynecol Scand. 2026. doi: 10.1111/aogs.70281. DOI: https://doi.org/10.1111/aogs.70281