Changes and Roles of IL-6, hsCRP, and proCT in Patients with Chronic Periodontitis in Head and Neck Cancer Pre/Post Radiotherapy

Authors

  • Ahmed Amer Al-Kubaisi Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar 31001, Iraq; Anah General Hospital, Al-Anbar Health Directorate, Anbar 31011, Iraq
  • Zaizafoon Nabeel Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq https://orcid.org/0000-0002-1758-7851
  • Şevki Adem Department of Chemistry, Faculty of Sciences, Çankırı Karatekin University, 18100 Çankırı, Turkey https://orcid.org/0000-0003-2146-5870
  • Layth Mula-Hussain Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada

DOI:

https://doi.org/10.54133/ajms.v7i1.1248

Keywords:

Cytokines, Head and neck cancer, , Periodontal disease, Radiotherapy

Abstract

Background: Head and neck cancer (HNC) patients frequently undergo radiotherapy as a standalone treatment or in combination with chemotherapy. Radiotherapy is associated with adverse effects, including detrimental impacts on periodontal health, which increase the risk of periodontitis. Objective: To investigate the clinical significance of interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP), and procalcitonin (proCT) as prognostic indicators. Methods: 150 participants were divided into three groups: (n=50, HNC post-RT) patients with head and neck cancer who had radiation treatment six months ago (n=50, HNC pre-RT), and individuals with periodontal health as the control group (n=50). Probing pocket depth (PPD), clinical attachment loss (CAL), gingival bleeding index (GBI), plaque index (PI), and hyposalivation were meticulously recorded. To quantify serum concentrations of IL-6, hs-CRP, and proCT, an electrochemiluminescence immunoassay (eCLIA) was used. Results: Serum levels of IL-6, hsCRP, and proCT were significantly elevated in two groups of patients with chronic periodontitis with head and neck cancer post-radiotherapy (CP+HNC post-RT) and patients with chronic periodontitis with HNC pre-radiotherapy (CP+HNC pre-RT) compared to a control group. ROC analysis demonstrated the diagnostic accuracy of IL-6, hsCRP, and proCT for both clinical cases. Furthermore, all clinical periodontal index scores (CAL, PPD, PI, and GBI) were significantly elevated compared to a control group. Conclusions: HNC post-RT patients presented significantly higher serum IL-6, hs-CRP, proCT, and periodontal score levels than HNC pre-RT.

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Published

2024-09-25

How to Cite

Al-Kubaisi, A. A., Nabeel, Z., Adem, Şevki, & Mula-Hussain, L. (2024). Changes and Roles of IL-6, hsCRP, and proCT in Patients with Chronic Periodontitis in Head and Neck Cancer Pre/Post Radiotherapy. Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), 7(1), 248–254. https://doi.org/10.54133/ajms.v7i1.1248

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