Relationship Between Human Cytomegalovirus and IL-17A in Iraqi Women with Polycystic Ovary Syndrome

Authors

  • Zahraa Mushrq Hadi Khorsheed Department of Microbiology, College of Medicine, Babylon University, Hilla, Iraq https://orcid.org/0009-0005-5645-5770
  • Ifad Kerim Abd Al-shibly Department of Microbiology, College of Medicine, Babylon University, Hilla, Iraq
  • Asmaa Kadhim Gatea Department of Obstetrics and Gynecology, College of Medicine, Babylon University, Hilla, Iraq

DOI:

https://doi.org/10.54133/ajms.v6i2.939

Keywords:

Human cytomegalovirus, Interleukin-17, Immunological regulator, Polycystic ovary syndrome

Abstract

Background: Evidence indicates a potential link between PCOS and low-grade infections. IL-17, also known as IL-17A, is an essential immunological regulator, especially in disorders such as polycystic ovarian syndrome (PCOS). The human cytomegalovirus is a β-herpesvirus that causes inflammation and remains dormant in the host for life. The cytomegalovirus has been central to several PCOS-related concepts. The role of IL-17A in CMV infection remains unknown. Objective: To establish the correlation between PCOS and CMV, as well as the connection between PCOS and serum levels of IL17A. Methods: A case-control study included 60 women with PCOS compared to 40 healthy controls. Samples were analyzed regarding CMV via the real-time PCR technique. Furthermore, the ELISA technique measured serum levels of the IL-17A cytokine. Every sample was taken between September 2023 and January 2024. Results: Positive results for CMV were seen in 50 (83.3%) of patients with PCOS compared with 10 (16.7%) who had negative results, while 6 (15.0%) of healthy control subjects had positive results and 34 (85.0%) had negative results; the difference was highly significant. Furthermore, women with polycystic ovary syndrome had a significantly higher IL-17A serum level when compared to healthy controls. Conclusions: In Iraqi women, HCMV infection in patients with PCOS can be considered a risk factor. Moreover, the results show that IL-17A is an excellent prognostic marker of polycystic ovary syndrome.

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Published

2024-06-17

How to Cite

Hadi Khorsheed, Z. M., Al-shibly, I. K. A., & Gatea, A. K. (2024). Relationship Between Human Cytomegalovirus and IL-17A in Iraqi Women with Polycystic Ovary Syndrome. Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), 6(2), 178–181. https://doi.org/10.54133/ajms.v6i2.939

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